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111In-Oxine-labelled autologous leucocytes in inflammatory bowel disease: New scintigraphic activity index

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111In-Oxine-labelled autologous leucocytes in inflammatory bowel disease: New scintigraphic activity index

Auteurs : RBID : ISTEX:259_1986_Article_BF00253298.pdf

English descriptors

KwdEn :
- Inflammatory bowel disease, 111Indium-leucocytes.

Abstract

The usefulness of scintigraphy with 111In-oxinelabelled autologous leucocytes was investigated in 27 patients with inflamatory bowel disease (IBD): 16 with ulcerative colitis and 11 with Crohn's disease. Scans were performed 2–4 h (early scan) and at 24 h (late scan) after leucocyte reinjection. No false-negative results occurred in the early scan; however, in the late scan, 2 patients with Crohn's disease had a normal scintigram. A new index of activity (Il) based on the number and relative activity of abnormal 111In-leucocyte zones was used for scan quantitation. All patients with clinically active IBD had Il≧2. The scintigraphic index showed a significant correlation with the Harvey clinical index, especially in patients with ulcerative colitis. Our results suggest that an early scan (2–4 h) provides useful information in cases of IBD, and that Il≧2 is indicative of the degree of disease activity in such patients.

DOI: 10.1007/BF00253298

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Le document en format XML

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<author><name>A. Ybern</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Nuclear Medicine, Hospital de Bellvitge ‘Princeps d'Espanya’, Hospitalet de Llobregat, Barcelona, Spain</mods:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Nuclear Medicine, Hospital de Bellvitge ‘Princeps d'Espanya’, Hospitalet de Llobregat, Barcelona</wicri:regionArea>
<wicri:noRegion>Barcelona</wicri:noRegion>
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<author><name>J. Martin-Comin</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Nuclear Medicine, Hospital de Bellvitge ‘Princeps d'Espanya’, Hospitalet de Llobregat, Barcelona, Spain</mods:affiliation>
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<wicri:regionArea>Department of Nuclear Medicine, Hospital de Bellvitge ‘Princeps d'Espanya’, Hospitalet de Llobregat, Barcelona</wicri:regionArea>
<wicri:noRegion>Barcelona</wicri:noRegion>
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<author><name>J. J. Giné</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Gastroenterology, Hospital de Bellvitge ‘Princeps d'Espanya’, Hospitalet de Llobregat, Barcelona, Spain</mods:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Gastroenterology, Hospital de Bellvitge ‘Princeps d'Espanya’, Hospitalet de Llobregat, Barcelona</wicri:regionArea>
<wicri:noRegion>Barcelona</wicri:noRegion>
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<author><name>T. Casanovas</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Gastroenterology, Hospital de Bellvitge ‘Princeps d'Espanya’, Hospitalet de Llobregat, Barcelona</wicri:regionArea>
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<author><name>R. Villa</name>
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<author><name>M. A. Gassull</name>
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<front><div type="abstract" xml:lang="eng">The usefulness of scintigraphy with 111In-oxinelabelled autologous leucocytes was investigated in 27 patients with inflamatory bowel disease (IBD): 16 with ulcerative colitis and 11 with Crohn's disease. Scans were performed 2–4 h (early scan) and at 24 h (late scan) after leucocyte reinjection. No false-negative results occurred in the early scan; however, in the late scan, 2 patients with Crohn's disease had a normal scintigram. A new index of activity (Il) based on the number and relative activity of abnormal 111In-leucocyte zones was used for scan quantitation. All patients with clinically active IBD had Il≧2. The scintigraphic index showed a significant correlation with the Harvey clinical index, especially in patients with ulcerative colitis. Our results suggest that an early scan (2–4 h) provides useful information in cases of IBD, and that Il≧2 is indicative of the degree of disease activity in such patients.</div>
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<abstract lang="eng">The usefulness of scintigraphy with 111In-oxinelabelled autologous leucocytes was investigated in 27 patients with inflamatory bowel disease (IBD): 16 with ulcerative colitis and 11 with Crohn's disease. Scans were performed 2–4 h (early scan) and at 24 h (late scan) after leucocyte reinjection. No false-negative results occurred in the early scan; however, in the late scan, 2 patients with Crohn's disease had a normal scintigram. A new index of activity (Il) based on the number and relative activity of abnormal 111In-leucocyte zones was used for scan quantitation. All patients with clinically active IBD had Il≧2. The scintigraphic index showed a significant correlation with the Harvey clinical index, especially in patients with ulcerative colitis. Our results suggest that an early scan (2–4 h) provides useful information in cases of IBD, and that Il≧2 is indicative of the degree of disease activity in such patients.</abstract>
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<topic>111Indium-leucocytes</topic>
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<titleInfo><title>European Journal of Nuclear Medicine</title>
<partNumber>Year: 1986</partNumber>
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<part><extent unit="pages"><start>341</start>
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111In-Oxine-labelled autologous leucocytes in inflammatory bowel disease: New scintigraphic activity index

111In-Oxine-labelled autologous leucocytes in inflammatory bowel disease: New scintigraphic activity index

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri